Autoimmunity: Altered self‐ N ‐glycans trigger innate‐mediated autoimmunity
نویسندگان
چکیده
منابع مشابه
Oxidative Stress, Altered-Self and Autoimmunity
It is well known that oxidative stress can induce production of free radicals that can modify proteins. The hypothesis presented here is that the target antigens in autoimmune diseases, such as type 1 diabetes mellitus, are not normal self proteins but rather self proteins that have been altered by free radicals, produced as a result of oxidative stress in the target cells. The observation that...
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Postpartum thyroiditis, a condition in which the thyroid gland swells, occurs in approximately five to seven percent of women within two to four months after delivery of a baby, and is the result of autoimmune disease. This is another common culprit for postpartum depression. Thyroiditis presents as a painless, small, firm goiter, or enlarged thyroid gland. Typically the woman notices either an...
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T cell tolerance depends on the presentation of selfproteins to T cells and therefore can only be established to those self-determinants which, under steady-state conditions, are generated in sufficient amounts to be recognized by T cells undergoing deletion in thymus or anergy in the periphery. Thus, there is large number of self-determinants that are cryptic because they are not generated at ...
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Herein we will review the role of glycans in the immune system. Specific topics covered include: the glycosylation sites of IgE, IgM, IgD, IgE, IgA, and IgG; how glycans can encode "self" identity by functioning as either danger associated molecular patterns (DAMPs) or self-associated molecular patterns (SAMPs); the role of glycans as markers of protein integrity and age; how the glycocalyx can...
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Modifications of both DNA and protein by methylation are key factors in normal T and B cell immune responses as well as in the development of autoimmune disease. For example, the failure to maintain the methylation status of CpG dinucleotides in DNA triggers T cell autoreactivity. Methylated proteins are known targets of autoimmunity, including the symmetrical dimethylarginine residues of SmD1 ...
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ژورنال
عنوان ژورنال: Immunology & Cell Biology
سال: 2007
ISSN: 0818-9641,1440-1711
DOI: 10.1038/sj.icb.7100122